Dr. Manav Pathania

Biography

Manav Pathania is a research group leader at the CRUK Cambridge Centre for Neuro-Oncology and Onco-Innovation Programmes. His research focuses on developmental neurobiology, epigenetics, and stem cell science, particularly in relation to paediatric high-grade glioma. He employs various genomic approaches to uncover the roles of chromatin remodeling in glioma initiation, maintenance, and therapy resistance. Pathania's specific techniques include the development of de novo glioma models using in utero electroporation with transposons and CRISPR vectors, as well as transgenic models. His expertise also covers vivo imaging techniques like bioluminescence, histology, and immunofluorescence, alongside single-cell dissociation techniques. He conducts research involving neural stem cells, employing methods for culture, stereotactic injection, and analysis of quiescence, proliferation, and differentiation. Further, his proficiency includes flow cytometry, various genomics techniques such as RNA-seq and ChIP-seq, molecular biology, biochemistry, and cloning. For further details on his research standards and contributions in the field of neuro-oncology, see the Pathania Lab website.

Research Interests