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Manu Ben Johny is an Assistant Professor in the Department of Physiology and Cellular Biophysics at Vagelos College of Physicians and Surgeons. His research interests lie at the intersection of quantitative physiology and molecular biophysics, employing engineering principles to study and manipulate ion channel signaling complexes that are critical for neurological and cardiovascular function. He aims to elucidate sophisticated spatiotemporal feedback regulatory mechanisms of cytosolic signaling molecules, specifically focusing on how messengers such as calcium ions tune the function of voltage-gated sodium and calcium channels. Dr. Johny also seeks to exploit his depth of understanding in emerging protein engineering methods to develop next-generation optogenetic synthetic modulatory tools, which can finely tune channel function. His work utilizes a variety of state-of-the-art methods, including fluorescence microscopy, photouncaging, low-noise single-channel whole-cell electrophysiology, quantitative modeling, and molecular simulations.
Exact Department Name: Department of Physiology and Cellular Biophysics. Program: Cellular and Molecular Physiology & Biophysics.