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Marc Chanson leads a research group focusing on cystic fibrosis, particularly on the role of gap junctions in the disease. His research addresses the molecular basis of cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations that result in chronic conditions such as pancreatitis and bronchitis. With a particular emphasis on understanding how cystic fibrosis epithelial cells show heightened susceptibility to stress and infections, Chanson investigates the exaggerated innate immune responses and abnormal tissue repair mechanisms in these cells. The research employs a comprehensive approach that includes cell biology, electrophysiology, and imaging techniques across various models, from cell lines to primary cultures of human airway epithelial cells and transgenic animal models. His work aims to unveil the intracellular signaling pathways linking CFTR to gap junctions and their roles in regulating host immunity responses to infections, potentially identifying new pharmacological targets for modulating these immune responses.
Includes Department of Management, Finance, Economics, and Statistics programs. GMAT is strongly encouraged but not mandatory for most GSEM masters.