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Marc de la Roche is a researcher in the Department of Biochemistry at the University of Cambridge, focusing on the Wnt signaling pathway and its implications in cancer. His work explores how this pathway regulates gene expression programs that govern stem cell behavior and intestinal epithelial function. Utilizing organoids as a model system, he studies the effects of oncogenic mutations and aims to discover molecular mechanisms that could serve as therapeutic targets for colorectal cancer. Key publications include insights into novel immunotherapeutics targeting LGR5 across multiple cancer types and investigations into the Hedgehog signaling pathway's role in Th17 polarization. Marc's laboratory is dedicated to finding strategies to prevent tumor development and characterizing the impact of specific mutations, such as those involving the APC tumor suppressor. His research addresses the vulnerabilities of intestinal epithelia to oncogenic mutations, aiming to enhance both molecular and clinical understanding of colorectal cancer.
Standard postgraduate requirements for Department of Politics and International Studies (POLIS) and related humanities departments.