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Marc V. Fuccillo, M.D., Ph.D., is an Associate Professor in the Department of Neuroscience at the Perelman School of Medicine, University of Pennsylvania. His research focuses on the synaptic circuit mechanisms that control behavior, particularly how neural circuits in the striatum regulate both simple motor patterns and complex goal-directed actions. He employs a range of technologies to explore the molecular, synaptic, and behavioral aspects of these circuits, aiming for a comprehensive understanding of normal striatal function and its disruption in mouse models of neuropsychiatric diseases. Fuccillo's lab is particularly interested in understanding autism-associated abnormalities in behavioral control, working with genetic mouse models to investigate the circuit and synaptic bases of these behaviors. His work involves using viral injections and genetic manipulation to study circuit function and synaptic transmission in specific neuronal populations, addressing how striatal circuits interact with other brain regions to guide behavior. His innovative approaches include single-cell transcriptomic analysis and microfluidics-based quantitative-PCR technology to characterize synaptic adhesion molecules that contribute to synaptic specificity and resilience against genetic insults.
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