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Marco Hoekman focuses on the molecular mechanisms involved in cortical development and neural stem cell maintenance. His research emphasizes transcription factors that shape the developing and adult brain, particularly investigating FoxO transcription factors' roles in neuronal migration and differentiation. Key findings include the discovery of FoxO6 and its importance in the transcriptional regulation of semaphorin-linked PlxnA4 for correct neuronal migration during embryonic cortical development. Current studies delve into the maintenance of adult neural stem cells and the metabolic and circadian influences on their quiescent state. Collaboration with experts such as Dr. Chaves and Prof. G. van der Horst has revealed insights into the regulatory pathways linking FoxO3 signaling and circadian rhythm modulation. Hoekman's investigations make significant contributions to understanding the complexities of brain development.
University of Amsterdam • Amsterdam, Netherlands
Conducting advanced research on transcription factors and their role in brain development.
Includes departments like Economics, Business Administration, Finance, and Marketing.