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Dr. Clark’s laboratory has a long-standing interest in B cell antigen receptor (BCR) signaling and how BCR-dependent processes regulate specific cell fate decisions. In the bone marrow, his research focused on understanding signals initiated by the pre-BCR, in conjunction with delivery via the IL-7 receptor, that coordinate cell cycle progression and immunoglobulin light chain gene recombination. This work led to the discovery of the epigenetic reader BRWD1 as a critical regulator of Ig-kappa coordination, fundamentally revising the canonical model of B lymphopoiesis. His laboratory has also developed novel in vivo models and conducted targeted in vitro studies to deepen understanding of these complex processes. Additionally, Dr. Clark explored how adaptive immune responses contribute to tubulointerstitial inflammation in human lupus nephritis, employing deep machine learning for innovative image analysis to quantify functional relationships between T cell and antigen-presenting cell populations. Notably, his bioinformatics platform achieves sensitivity and specificity comparable to two-photon excitation microscopy, applicable for the study of human disease, and utilizes single-cell technologies to investigate B cell selection sites and the interplay between transcriptional state and antigenic specificity.
Department of Philosophy