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Margaret Ashcroft's research focuses on the key cellular mechanisms involved in oxygen sensing and hypoxia signalling in mammalian cells. With a particular emphasis on the hypoxia inducible factor (HIF) family of transcription factors, her work investigates their roles in diseases such as cancer, renal disease, and cardiovascular disease. The Ashcroft laboratory aims to evaluate known and novel regulators of hypoxia/HIF signalling, especially the connection between mitochondria and cellular oxygen-sensing machinery. The research also delves into the cellular mechanisms that regulate hypoxia/HIF signalling in mammalian cells, linking these processes to various diseases. Additionally, Ashcroft's team seeks to identify and develop strategies to exploit hypoxia/HIF signalling for therapeutic purposes.
Standard postgraduate requirements for Department of Politics and International Studies (POLIS) and related humanities departments.