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Maria-Luisa Alegre, MD, PhD, is a Professor in the Biological Sciences Division at the University of Chicago. Her research focuses on the mechanisms of immune tolerance in transplantation, autoimmunity, and cancer, utilizing a strong foundation in mouse models with growing emphasis on clinical translation. Dr. Alegre leads a laboratory that investigates how infections and inflammatory events influence T cell tolerance and responses, particularly in the context of transplantation. Her research has shown that the robustness of transplantation tolerance varies, depending on the mechanisms of T cell tolerance activated. Significant findings include the role of microbiota in modulating immune responses and transplant outcomes, highlighting new therapeutic opportunities. In collaborative efforts, Dr. Alegre has also extended her research to explore the impact of microbiota on melanoma patients' responses to immunotherapy. She has a rich background in clinical and experimental immunology, with publications in leading journals and active participation in various esteemed committees, including a leadership position in the American Association of Immunologists.
University of Chicago • Chicago, IL
Professor in the Biological Sciences Division, focusing on immunology and transplantation.
Department of Philosophy