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Maria-Luisa Alegre leads a research laboratory focused on T cell responses in contexts of transplantation, autoimmunity, and cancer, with a strong foundation in mouse models and a growing emphasis on clinical translation. The primary focus of her lab is understanding T cell tolerance in transplantation and how infections and inflammatory events influence the induction and maintenance of this tolerance. Her work has demonstrated that transplantation tolerance exists on a spectrum of robustness, depending on the mechanisms of T cell tolerance activated. Notably, infections and inflammation can compromise these mechanisms, eroding tolerance. Her investigations have revealed how bacterial infections impact transplant outcomes by directly modulating immune responses related to the microbiota. Dr. Alegre's team has shown that manipulating the microbiota can enhance graft survival, presenting new therapeutic opportunities.
University of Chicago • Chicago IL
Teaching and conducting research in immunology and transplantation.
Department of Philosophy