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Maria-Luisa Alegre is a Professor in the Department of Medicine at the University of Chicago, specializing in Immunology and Transplantation. Her research focuses on T cell responses in the contexts of transplantation, autoimmunity, and cancer, with a strong emphasis on translating findings from mouse models to clinical applications. Dr. Alegre's laboratory investigates the mechanisms of T cell tolerance, particularly how infections and inflammatory events influence the induction and maintenance of this tolerance. Her work has shown that transplant tolerance exists on a spectrum of robustness, with critical implications for patient outcomes. Through her investigations, she has revealed that bacterial infections can directly affect transplant outcomes by modulating immune responses via alterations in microbiota. Dr. Alegre's recent studies aim to manipulate microbiota to enhance graft survival, opening new avenues for therapeutic strategies in transplantation. Additionally, her collaborative research explores the impact of microbiota on the responsiveness of melanoma patients to immunotherapy, bridging fundamental immunology with translational and clinical applications.
University of Chicago • Chicago, IL
Leader of a research laboratory focused on T cell responses in transplantation and autoimmune diseases.
Department of Philosophy