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Maria Isabel Dominguez is an Assistant Professor at Boston University Chobanian & Avedisian School of Medicine, specializing in Hematology and Medical Oncology. Dominguez's research focuses on the role of Wnt/ß-catenin signaling components in post-fertilization organ development, with implications for cancer and congenital diseases. She has significantly contributed to the understanding of Ser/Thr kinases CK2 and GSK3ß in Wnt/ß-catenin signaling during embryonic development, leading to the identification of novel mechanisms and paradigm shifts within the field. Her innovative work has been published widely, influencing both academic and popular literature. Dominguez uses a combination of experimental and computational approaches in her lab, with research funded by both federal and non-federal agencies. Her primary research interests include defining the molecular biological mechanisms underlying rare human neurodevelopmental disorders like Okur-Chung and Poirier-Bienvenu Syndromes, elucidating the activation mechanisms of Wnt/ß-catenin signaling, and determining alterations in CK2 genes across various tumor types. As an educational leader, she has developed career training programs for biomedical professionals, emphasizing mentorship and inclusion in science. She also serves as a faculty advisor for multiple programs and committees focused on fostering diversity within the biomedical workforce.
Boston University Chobanian & Avedisian School of Medicine • Boston, MA
Research and teaching in Hematology and Medical Oncology.
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