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Marisa S. Bartolomei is a Professor in the Department of Cell Developmental Biology at the University of Pennsylvania. She received her B.S. in Biochemistry from the University of Maryland, College Park in 1982, and her Ph.D. from Johns Hopkins University School of Medicine in 1987, specializing in Cellular & Molecular Biology. Her research focuses on genomic imprinting and X inactivation in mice, exploring the genetic mechanisms that govern these processes. The laboratory studies the unequal expression of maternal and paternal alleles, essential for normal mammalian development. Key research interests include DNA methylation, epigenetics, and the impact of environmental factors, such as endocrine disruptors, on genomic imprinting and gene regulation. Bartolomei's work also investigates the complex mechanisms of X inactivation in female mammals, studying how the process achieves dosage compensation. Through collaboration and innovative methodologies, her research aims to clarify the molecular genetic controls of these critical biological phenomena.
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