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Mark Applebaum, MD, is an expert in pediatric cancers and blood diseases, with a special interest in the treatment of neuroblastoma, sarcomas, and solid tumors. Dr. Applebaum is a translational physician-scientist who works to harness genomics and big data to advance treatments for children with neuroblastoma. He bridges the fields of epigenetics, genomics, and cancer biology to identify novel risk classifiers and therapeutic targets. His research focuses on specific epigenetic marks to identify patients with aggressive neuroblastoma who may benefit from alternatives to standard therapy. His laboratory investigates how the low-oxygen environment of tumors can make cancer cells resistant to standard therapies by inducing changes in epigenetic marks. Identifying the genes and cellular pathways responsible for these changes may ultimately open new avenues for novel therapeutic options. His research is supported by the National Cancer Institute and various foundations, including the Conquer Cancer Foundation and the Bear Necessities Foundation, and he has been recognized with numerous awards from professional organizations.
Department of Philosophy