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Professor Mark Arends is a leading researcher in the field of pathology, focusing on cancer and its progression. His research primarily deals with the identification and validation of new genes involved in the formation of neoplasms, especially colorectal cancer and its associated dysplastic lesions. His work integrates various methodologies, including molecular pathology and digital/computational approaches, to analyze human cancer samples and evaluate the genetic and epigenetic changes associated with carcinogenesis. He has made significant contributions towards understanding the role of defective mismatch repair in inflammatory bowel disease-associated colorectal cancer and has been involved in the study of cellular transitions from normal precursor lesions to malignant neoplasms. Additionally, Arends has researched various genetic alterations in colorectal tumors, including alterations in genes like APC and TP53. His laboratory utilizes a range of models to investigate the complexities of intestinal tumorigenesis and the mechanisms behind cancer development.
The University of Edinburgh • Edinburgh
Leading the pathology research group specializing in cancer research and educational supervision.
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