Dr. Mark Daly

Biography

Dr. Daly's lab focuses on computational approaches to understanding genetics and disease strategy, integrating powerful techniques in human and mouse genetics. The lab has extensive experience in linkage and association analysis, with a concentrated effort over the past decade on developing analytical tools and methodologies for the study of genetic variation using resources like HapMap. Their focus has shifted towards the aggressive application of these approaches in major common disease areas, particularly Crohn's disease and autism. Dr. Daly's research aims at discovering genes involved in human disease, which is seen as a critical step in a long-term research agenda committed to identifying, understanding, and therapeutically intervening in currently unknown pathways underlying common human diseases. Ongoing research in the lab encompasses a broad focus on computational and technological issues related to gene discovery, including the characterization of patterns of genetic variation, the interpretation and analysis of novel genetic data from genotyping and sequencing technologies, and the development of statistical methodologies necessary for utilizing this information in disease studies. The lab emphasizes cross-disciplinary and comprehensive approaches in the genetics of human disease and actively collaborates with clinical and molecular expertise both locally and internationally to enhance the clinical and therapeutic relevance of their findings.

Research Interests