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Mark Glover is a Professor in the Department of Biochemistry at the University of Alberta, where he leads research focused on the structural biology of proteins involved in DNA repair and transcription. He employs a combination of structural and biochemical techniques to investigate the functions of proteins crucial for maintaining genome integrity, thereby providing insights into cancer defense mechanisms. His investigations have elucidated the structure and function of the BRCT domain of BRCA1, a vital tumor suppressor, and have paved the way for understanding the mechanistic roles of other proteins like the mammalian polynucleotide kinase. Glover’s research also encompasses the study of plasmid DNA architecture and the regulation of transcription factors such as Ndt80 in yeast, contributing to the understanding of gene expression during meiosis and sporulation. With numerous publications, Glover's work continues to influence the fields of cellular response to DNA damage and the development of potential therapeutic strategies for cancer treatment.
University of Alberta • Edmonton, AB
Leads research in structural biology and biochemistry, focusing on DNA repair processes and cellular responses to DNA damage.
Department: Mechanical Engineering and Engineering Management