Dr. Mark Goulian

Biography

Mark D. Goulian is a faculty member at the Perelman School of Medicine at the University of Pennsylvania, focusing on microbial regulatory circuits and signal transduction. His research primarily investigates the two-component signaling systems in bacteria, particularly Escherichia coli, to understand how these systems mediate responses to environmental signals. The Goulian lab employs a variety of techniques, including genetics, bacterial physiology, fluorescence microscopy, and mathematical modeling, to explore the design principles that underlie these intricate signaling systems. His work often involves engineering synthetic networks through rational design and directed evolution to construct novel signaling circuits. A notable aspect of his research is the application of techniques to measure signaling activity at the single-cell level, enhancing the understanding of these biological processes.

Research Interests