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Mark Hedglin is an Associate Professor in the Department of Chemistry at Pennsylvania State University. His research is centered on understanding the mechanisms of human DNA replication, focusing on how the genome maintains fidelity during cell division. His team employs a multidisciplinary approach, combining biophysical, biochemical, and molecular biology techniques to identify cellular factors that are critical for the reproduction of DNA and to reconstitute human DNA replication in various biological scenarios. Significant aspects of his work investigate the modifications that DNA and associated proteins undergo in response to environmental stresses and how these alterations impact replication fidelity. He has received the NIH Ruth L. Kirschstein NRSA Postdoctoral Fellowship. Throughout his career, he has published numerous peer-reviewed articles that shed light on the complexities of DNA polymerases and replication processes, contributing to the broader understanding of cellular responses to DNA damage and replication stress.
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