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Mark Nitz is a Professor in the Department of Chemistry at the University of Toronto. His research focuses on Biological Chemistry and Organic Chemistry, with a particular interest in Mass Cytometry and Reagent Development. Nitz has been instrumental in advancing the potential of Mass Cytometry as a technique that enables the simultaneous measurement of numerous proteins, metabolites, and transcripts at the cellular level. His work involves the generation of new reagents that facilitate Mass Cytometry, utilizing heavier atoms to introduce structures that are essential for biochemical probes. He investigates carbohydrate derivatives to inhibit bacterial glycobiology, emphasizing the impact of sugars on bacterial cell structures and biofilm formation, particularly poly-N-acetylglucosamine (PNAG). Nitz also specializes in synthetic inhibitors characterized in vitro to understand their mode of action and inhibition constants. His collaborative studies solve co-crystal structures within bacterial systems to better understand these biological processes. Additionally, he explores novel bioorthogonal chemistry and the development of new chemical applications in biology.
Department of Sociology