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Markus Diefenbacher is a group leader at the Diefenbacher Lab, Helmholtz Munich, focusing on experimental oncology. The lab investigates novel therapeutic approaches to lung cancer, which is a significant health challenge worldwide. With lung cancer projected to have nearly 3.8 million cases by 2050, the lab aims to develop advanced models that reveal the interaction between tumor genetics and the tumor microenvironment. Using state-of-the-art techniques such as CRISPR/Cas9 and patient-derived organoids, the team explores the regulation of biological processes by the ubiquitin-proteasome system in tumor cells. The research also targets essential pathways with the potential to develop personalized therapies for lung cancer patients. Diefenbacher’s lab has developed simplified protocols for culturing primary organoids derived from murine and human tissues to study the early consequences of oncogenic transformation and to test innovative therapeutic strategies against lung cancer variations.
Diefenbacher Lab, Helmholtz Munich • Munich, Germany
Leading a research group focused on lung cancer and experimental oncology.