Dr. Markus Lill

Biography

Dr. Markus Lill received his Diploma in Physics from the University of Erlangen-Nürnberg, Germany, and his Ph.D. from the Max Planck Institute for Biophysics in Frankfurt, Germany. He completed years of postdoctoral training at the Biographics Laboratory 3R in Basel, Switzerland, where he was promoted to project leader in ADMET research. He was also a reader in the Department of Pharmaceutical Sciences at the University of Basel, completing his Habilitation in 2006. Dr. Lill started his academic career as an Assistant Professor at Purdue University and was promoted to tenured Associate Professor in 2012. From 2014 to 2016, he served as a Visiting Scientist at the German Cancer Research Center in Heidelberg. In 2019, he was appointed Professor of Computational Pharmacy in the Department of Pharmaceutical Sciences at the University of Basel. His research interests involve the development and application of computational methods for drug discovery, focusing on modeling protein-ligand and protein-protein interactions with particular attention to protein flexibility, dynamics, and solvation effects. His group utilizes docking techniques, simulations, similarity-based screening, QSAR, and deep learning, and he leads the development of 13 software products. These computational methods are applied in collaboration with experimental groups across a variety of disease targets including GPCRs, nuclear receptors, cyclooxygenases, and adenylyl cyclases, as well as in predicting CYP-mediated drug metabolism and formulating peptide drugs to overcome aggregation.

Research Interests