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Martin Fischer's research focuses on exploring novel nonlinear optical contrast mechanisms for molecular imaging. His work in nonlinear optical microscopes provides non-invasive, high-resolution, three-dimensional images in highly scattering environments, like biological tissue. He has established contrast mechanisms, including two-photon fluorescence and harmonic generation, to enhance imaging of targets such as autofluorescent markers and connective tissue structures. He aims to develop techniques that utilize previously inaccessible interactions to create structural molecular image contrasts, employing ultrafast laser pulse shaping and detection methods that significantly improve measurement sensitivity. Fischer's applications of microscopy methods range from imaging biological tissues for structure mapping and characterization of nanomaterials, including graphene and gold nanoparticles, to creating pigment-specific signatures for paints in historic artwork conservation. He is also the director of the Advanced Light Imaging Spectroscopy (ALIS) facility at Duke University. His rich background merges physics and imaging science, with significant contributions to the fields of optics and photonics.
Department of Biomedical Engineering (MS program)