Dr. Martin Tanner

Biography

Professor Martin Tanner focuses on developing a detailed understanding of the mechanisms by which enzymes catalyze biological reactions. Insights gained from studies on enzyme mechanisms lead to the production of bioactive compounds and the design of efficient synthetic catalysts. Stereochemical control is a key component in the biosynthesis and metabolism of biological compounds; consequently, racemases and epimerases evolve to catalyze the inversion of configuration at carbon. His research includes studying enzymes that act on unactivated stereocenters employing unique reaction mechanisms. A notable example is the ADP-heptose 6-epimerase, which generates a key building block for bacterial lipopolysaccharide biosynthesis. His current interests lie in researching enzymes responsible for the biosynthesis of sialic acids in mammals, which are crucial for cellular recognition events. A wide range of experimental techniques is utilized to probe reaction pathways, including tools from physical organic chemistry, isotopic labeling studies, and synthetic organic chemistry for designing potent enzyme inhibitors. Molecular biology techniques are applied to produce large quantities of enzymes for site-directed mutagenesis experiments.

Research Interests

Experience