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Martin Zanni is the Meloche-Bascom Chair and Helfaer Professor at the University of Wisconsin–Madison. He leads a group focused on developing and applying new methods in two-dimensional infrared (2D IR) spectroscopy to study protein structures and their evolution. His research includes using 2D IR spectroscopy to uncover on-pathway toxic oligomeric intermediates of human islet amyloid polypeptide, which has implications for type II diabetes. Zanni has characterized the structure and cytotoxicity of these intermediates, which has led to the creation of a new mouse model of type II diabetes in collaboration with the Biotechnology Center at UW-Madison. His work also examines the impact of oligomers and fibrils on islet and acinar cell function. Notably, he has developed 2D IR bioimaging techniques that utilize microscopy and moving stages to create location-resolved maps of protein structures within human and mouse tissues.
Department: Department of Computer Sciences