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Mary Gehring researches epigenetic mechanisms of gene regulation in plants. Her focus is on plant epigenetics, specifically how heritable information influences cellular functions encoded in the DNA sequence. She employs genetic, genomic, and molecular biology approaches to study the fidelity of epigenetic inheritance, the dynamics of epigenomic reprogramming, and reproduction, primarily using the model plant Arabidopsis thaliana. Gehring investigates the interplay between repetitive sequences, DNA methylation, and chromatin structure in dynamic processes.