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The Anderson Lab focuses on the genetic diversity that contributes to variation within species populations. The lab addresses significant questions leveraging the major human fungal pathogen, Candida albicans, along with harmless commensal microorganisms found in the gastrointestinal tract. This yeast exhibits a remarkably adaptable genome capable of undergoing complete ploidy shifts, harboring aneuploidy, and experiencing extensive loss of heterozygosity, all while rapidly acquiring mutations. The research aims to uncover the mechanisms that lead to the expansion of gene families, elucidating the functional context of paralogs and defining the relationship between genotype and phenotype in the equilibrium between commensalism and pathogenesis. Furthermore, the lab develops systems to analyze the 'eukaryome' via metagenomics techniques, collaborating with Lakota partners to explore links between the human microbiome and autoimmunity.
Department: Department of Computer Sciences