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Matt Scaglione is an Associate Professor in the Department of Molecular Genetics and Microbiology at Duke University. His research focuses on the regulation of protein homeostasis (proteostasis) and its implications in neurodegenerative diseases. Scaglione employs a variety of model systems, including the social amoeba Dictyostelium discoideum, human cell cultures, and mouse models, to explore cellular pathways that address misfolded proteins. His ultimate aim is to advance the understanding of these pathways and develop strategies to enhance them, potentially leading to novel therapies for neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and polyglutamine diseases. He has received numerous grants from the National Institutes of Health for his work on protein quality control pathways and the mechanisms underlying neurodegeneration.
Department of Biomedical Engineering (MS program)