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Matthew Cook is a professor in Experimental Medicine at the University of Cambridge and an Honorary Consultant in Clinical Immunology at Addenbrooke's Hospital. He leads research focused on primary immune deficiency, autoimmunity, and the genetic underpinnings of immune diseases. Cook's work involves large patient cohorts to understand the cellular and genetic basis of human immune disorders, utilizing genomics and sophisticated modeling techniques to identify pathogenic variants. His laboratory aims to define the mechanisms behind T and B cell development and the defects therein, particularly focusing on NF-kB signaling pathways. By elucidating these pathogenic signatures, he strives to improve the stratification of patients suffering from both Mendelian and common immune diseases.
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