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Matthew D. Layne is an Associate Professor at Boston University in the Chobanian & Avedisian School of Medicine. He holds a PhD from Boston University School of Medicine and a BA from Boston University. His research focuses on the mechanisms regulating extracellular matrix (ECM) synthesis and assembly, particularly in relation to fibroproliferative connective tissue diseases. Layne's work explores the links between organic fibrosis, cardiovascular health, metabolic disease, obesity, and cancer pathologies, aiming to develop therapeutic strategies that impact these conditions. A significant aspect of his research investigates the role of Aortic Carboxypeptidase-like Protein (ACLP) in myofibroblast differentiation and its interaction with transforming growth factor beta (TGFβ) signaling pathways. He serves as the Assistant Dean for Research at Boston University and continues to mentor graduate students. His laboratory is involved in multiple projects, including exploring mutations related to Ehlers-Danlos syndrome and adipose tissue remodeling. Layne has published extensively and is recognized for his contributions to understanding severe ECM remodeling.
Boston University • Boston, MA
Teaching and conducting research in the field of Biochemistry & Cell Biology.
Boston University • Boston, MA
Oversight of research initiatives and mentoring graduate students.
Department of Law offers JD, LLM, and Master's in Study of Tax Law.