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Professor Matthew Murray leads research on the clinical and molecular aspects of childhood solid tumours, particularly germ cell tumours (GCTs) such as testicular cancer. His work explores the role of non-coding RNAs, particularly microRNAs, in regulating gene expression in cancer. Notably, he established the significant over-expression of the miR-371~373 and miR-302/367 clusters in malignant GCTs, independent of patient age, histological subtype, or anatomical site. He has demonstrated the potential for specific circulating microRNAs to aid in the diagnosis and monitoring of relapses in childhood tumours. Professor Murray's current research is focused on four main themes: the clonal dynamics of germ cell tumours, the role of the tumour microenvironment, novel therapeutic strategies to restore under-expressed microRNAs, and improving diagnostic methods for disease monitoring. His contributions have been documented in numerous publications, enhancing the understanding of microRNA involvement in cancer and highlighting the significance of serum microRNA profiles in risk stratification for prognosis in childhood cancers such as MYCN-amplified neuroblastoma.
University of Cambridge • Cambridge
Leading the Department of Pathology and conducting research on childhood cancers.
Standard postgraduate requirements for Department of Politics and International Studies (POLIS) and related humanities departments.