Generate a tailored SOP for Dr. Matthew Shoulders. Improve your application with a focused, well-structured draft.
Matthew D. Shoulders is a Class of 1942 Professor in the Department of Chemistry at the Massachusetts Institute of Technology. His research focuses on understanding how cells fold proteins and utilizing next-generation protein engineering directed evolution techniques to address various biotechnology challenges. Shoulders’ laboratory investigates cellular protein folding, specifically exploring how protein misfolding and aggregation lead to diseases, particularly related to the extracellular matrix and collagenopathies. Furthermore, he seeks to develop new treatments for these disorders by studying the impact of chaperones and quality control mechanisms on the mutational space accessible to client proteins, particularly those related to rapidly evolving RNA viruses. His biotechnology-oriented work includes the inventing of efficient in vivo directed evolution strategies aimed at creating valuable biotechnologies. Shoulders’ applications span a range of innovative genome targeting agents and improving enzymes that are key to biological carbon capture, which is vital for addressing climate change and supporting resilient agriculture.
Massachusetts Institute of Technology • Cambridge, MA
Leading research in protein folding and biotechnology.