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The Soellner laboratory focuses on cancer pharmacology, specifically developing novel therapeutics that utilize inhibitors to understand oncogenic signaling in breast cancer. The laboratory routinely conducts organic synthesis, medicinal chemistry optimization, and biochemical and cellular evaluations to assess potential therapeutics. Their research aims to identify mechanisms modulating kinase conformation, explore stabilizing kinase conformations using small molecules, and utilize findings to generate selective inhibitors that stabilize specific protein conformations to improve signaling inhibition. The laboratory has reported the development of highly selective c-Src kinase inhibitors, which are critical due to the attractive yet challenging nature of pharmacological approaches studying kinases. Soellner's work is characterized by his lab's commitment to make selective kinase inhibitors readily available to the scientific community, impacting the study of c-Src kinase in biological systems.
University of Michigan • Ann Arbor, MI
Teaching and conducting research in the field of chemistry, focusing on cancer pharmacology and the development of therapeutics.