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Maureen E. Murphy is a professor at the Wistar Institute and the Deputy Director of the Ellen Ronald Caplan Cancer Center. Her laboratory focuses on tumor suppressor proteins commonly mutated in human cancers, particularly p53 and p14ARF. These proteins regulate important processes such as cell death (apoptosis) and survival (autophagy). Dr. Murphy has a keen interest in understanding how genetic polymorphisms in the p53 tumor suppressor gene affect its ability to induce apoptosis and growth arrest, particularly in African American populations. Her work aims to reveal the inter-individual differences that influence cancer risk and therapy outcomes, especially as these genetic variants occur with high frequency in certain ethnic groups. Additionally, Dr. Murphy proposes targeting the autophagy pathway in cancer therapy by using small molecule inhibitors of Heat Shock Protein 70 (HSP70) to selectively eradicate tumor cells.
Wistar Institute • Philadelphia, PA
Serving as a professor and leading research in tumor biology.
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