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Megan L. Matthews is an Assistant Professor in the Department of Chemistry at the University of Pennsylvania. She holds a Bachelor of Science in Chemistry from Miami University, obtained in 2005, and a Ph.D. in Chemistry from Pennsylvania State University, awarded in 2011. Following her doctoral studies, she was a Merck Helen Hay Whitney Postdoctoral Fellow from 2012 to 2015 and subsequently served as a postdoctoral associate from 2015 to 2017 in the Department of Molecular Medicine at the Scripps Research Institute. Dr. Matthews' research interests focus on advancing enzymology and chemical biology through the development of innovative chemical proteomics technologies. Her work seeks to uncover novel enzyme cofactors and regulatory post-translational modifications that are not easily predicted from gene or protein sequences. Through her research group, she examines the roles of reactive electrophiles in the context of protein function and diseases, including cancer and Alzheimer's disease. Dr. Matthews aims to explore the uncharted territories of the reactive proteome by developing 'reverse-polarity' chemical probes that provide insights into the functional diversity and relevance of these modifications in disease contexts.
Department of Chemistry, University of Pennsylvania • Philadelphia, PA
Teaching and conducting research in the field of chemistry.
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