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The Alpaugh lab utilizes human tissue samples, mouse models, and cell culture systems to investigate protein misfolding in neurodegenerative diseases. Current research explores the role of tau in Huntington’s disease, the effects of cardiovascular disease on protein misfolding, and how environmental stressors influence protein aggregation. The overarching goal is to understand the mechanisms and consequences of protein misfolding. The laboratory employs a variety of methodologies, including behavioral analysis, biochemical methods, and complex statistical analysis, to gain insights into these conditions and their impact on human health.
Department of Clinical Studies. Offers MSc by thesis (2 years) and MSc by coursework (1 year).