Dr. Melike Lakadamyali

Biography

Melike Lakadamyali is a Professor in the Department of Physiology at the Perelman School of Medicine at the University of Pennsylvania. Her primary research interests include understanding macromolecular machines at a biological level to achieve a quantitative biophysical comprehension of the mechanisms that lead to vital cellular processes. She focuses on the development of advanced microscopy techniques aimed at enhancing the visualization of these biological processes at high spatiotemporal resolutions. Her work particularly emphasizes the transport machinery that drives intracellular trafficking and the transcriptional machinery that facilitates gene expression. Lakadamyali's research is grounded in the significant challenges presented by the interactions of multiple proteins, which form functional macromolecular complexes. She has made substantial contributions to the field, including pioneering developments in super-resolution microscopy that have permitted novel insights into vesicular transport and chromatin organization. Her research also adopts a highly quantitative biophysical stance, translating qualitative descriptions into precise quantitative models.

Research Interests