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Melissa Cudmore is a Career Development Fellow at the University of Edinburgh's Centre for Cardiovascular Science. Her research focuses on aberrant angiogenesis and its implications in various pathologies, particularly in ischaemic diseases and cancers. She investigates the roles of vascular endothelial growth factor (VEGF) and its receptors in the regulation of angiogenesis, an essential process in both physiological and pathological contexts. Despite previous challenges in targeting the VEGF signaling pathway, her work aims to deepen the understanding of the fine regulation of this system, particularly through the mechanisms of receptor heterodimerisation. By developing novel ligands specific to VEGFR-1-2 heterodimers, she is providing insights into how these receptors can modulate responses and regulatory functions within the vascular system. Her research contributes significantly to an evolving paradigm on the functional dynamics of VEGF receptors in vascular development and disease. Cudmore is committed to advancing therapeutic strategies that can more effectively target angiogenesis to improve clinical outcomes for patients suffering from angiogenesis-related diseases.
University of Edinburgh • Edinburgh
Conducting research on the mechanisms of angiogenesis and the role of VEGF receptors in various pathological conditions.
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