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Mengjie Chen leads the Chen Group at the University of Chicago, focusing on computational statistical genomics. The group develops computational tools to address the challenges posed by high-throughput genomics technologies for data analysis and interpretation. Key areas of research include single cell genomics, where the group works to account for unwanted variations caused by technical artifacts in single-cell experiments. Significant projects include methods for controlling confounding effects to maintain gene expression variability and developing strategies for the imputation and alignment of single-cell RNA-sequencing samples. The group also delves into epitranscriptomics, unveiling the RNA modifications that regulate gene expression dynamically. Their research encompasses differential methylation analysis, integrative studies of m6A modifications, and the exploration of genetic heterogeneity in cancer genomics to facilitate personalized treatment strategies. Chen integrates single cell RNA sequencing and bulk tissue DNA sequencing data to uncover tumor heterogeneity and improve diagnostic accuracy. The Chen Group invites students from various programs, particularly those in Human Genetics, Biostatistics, and Data Science, to collaborate and apply for available postdoctoral positions.
Department of Philosophy