Dr. Michael Angelo

Biography

Michael Angelo, MD PhD, is a board-certified pathologist and Associate Professor in the Department of Pathology at Stanford University School of Medicine. He leads a laboratory focused on high dimensional imaging, specializing in tissue homeostasis, tumor immunology, and infectious diseases. His lab has pioneered the development of Multiplexed Ion Beam Imaging time of flight (MIBI-TOF), utilizing secondary ion mass spectrometry with metal-tagged antibodies to achieve rapid, simultaneous imaging of dozens of proteins at subcellular resolution. Underscoring his achievements, Dr. Angelo received the NIH Director’s Early Independence Award in 2014. His lab's innovative technology has unveiled previously unknown principles governing the spatial organization of cellular composition within the tumor microenvironment, particularly in triple negative breast cancer. The findings have identified predictive single-cell expression profiles for immunotherapy drug targets, significantly impacting 10-year overall survival. His ongoing research aims to elucidate the structural mechanisms in the tumor microenvironment that promote the recruitment of cancer-associated fibroblasts and tumor-associated macrophages, alongside extracellular matrix remodeling. Dr. Angelo is a recipient of the 2020 DOD Era of Hope Award and serves as the principal investigator for multiple extramural awards from organizations such as the National Cancer Institute and the Breast Cancer Research Foundation.

Research Interests

Courses