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Michael L. Atchison is a faculty member at the University of Pennsylvania's Perelman School of Medicine, affiliated with the Graduate Group in Biomedical Sciences. He holds a B.S. in Biology from SUNY Albany and a Ph.D. in Cell Molecular Biology from New York University School of Medicine. His research focuses on the molecular mechanisms of transcriptional regulation and epigenetic processes, particularly regarding B cell lineage commitment and hematopoietic plasticity. Atchison's lab investigates the role of the transcription factor YY1 in these processes, including how YY1 facilitates long-range chromatin interactions and repressive histone modifications. His studies employ various molecular techniques such as Hi-C, ChIP-seq, and RNA-seq to explore the fidelity and functionality of T lineage cells developed from YY1-null pro-B cells. His work aims to uncover universal mechanisms of lineage commitment that can be manipulated for therapeutic purposes.
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