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Dr. Michael Brown’s research focuses on leveraging intratumor innate immunity for cancer immunotherapy, particularly in malignant brain tumors. His lab employs mouse cancer models, ex vivo human tumor slice culture assays, and clinical trial-associated specimens to decode the mechanisms by which intratumoral innate immune cells control cancer immune surveillance. The lab is dedicated to developing novel therapeutic approaches to engage endogenous antitumor T cells. Dr. Brown collaborates with clinicians and research groups to facilitate the translation of novel therapies, define the determinants of successful immunotherapy, and elucidate mechanisms explaining immune dysfunction in patients with cancer.
Duke Cancer Institute • Durham, NC
Member of the Duke Cancer Institute, focusing on cancer immunotherapy research.
Department of Biomedical Engineering (MS program)