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Michael Douglas is a Professor Emeritus in the Department of Biochemistry at Duke University. His research focuses on various aspects of RNA self-processing systems, including self-cleaving RNA sequences (ribozymes) and the hepatitis delta virus (HDV) RNA splicing activity associated with group introns. He has extensively studied the HDV, a significant human pathogen linked to satellite hepatitis B virus, and its implications for severe liver conditions. His work has aimed to elucidate the structure and function of the key elements involved in the replication of this virus, particularly the self-cleaving RNA sequences. Professor Douglas has also investigated the tertiary structure of ribozymes using innovative chemical techniques. His studies on group intron RNA splicing explore the evolutionary relationships and functional mechanisms of these self-splicing elements in distinct organisms, particularly fungi. Over the years, he has received multiple grants from the National Institutes of Health to support his research endeavors.
Duke University • Durham, NC
Focused on research in biochemistry, specifically in RNA self-processing and hepatitis delta virus.
Department of Biomedical Engineering (MS program)