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Michael Eck is a Professor in the Department of Biological Chemistry and Molecular Pharmacology. He focuses on the regulation of cell signaling and actin cytoskeleton through structural biochemical approaches, aiming to uncover fundamental mechanisms of signaling in response to cellular changes. His research particularly emphasizes the dysregulation of kinases in cancer and the control of actin assembly through formin proteins. His active projects include studying focal adhesion kinase (FAK) interactions with integrins and Src-family kinases, as well as the impact of lung cancer-derived mutations in the epidermal growth factor receptor (EGFR). Eck's innovative work has led to understanding the molecular interactions that release the autoinhibition of FAK, facilitating insights into its role in cell morphology and migration, which are critical in the invasiveness of human tumors.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).