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Michael Kolbe is a Group Leader at the Helmholtz Centre for Infection Research and is affiliated with the University of Hamburg. His research focuses on medically relevant Gram-negative pathogens and their mechanisms of infection, particularly the structural and functional aspects of Type III Secretion Systems (T3SS). Kolbe's work aims to elucidate the structural switches in bacterial secretion apparatuses and to understand the molecular interactions between T3SS effector proteins and host components. Through interdisciplinary approaches, including high-end imaging technologies and biophysical methodologies, he explores the dynamics of bacterial infection and develops strategies to combat antibiotic resistance in pathogens such as Pseudomonas aeruginosa. His future research goals include identifying novel bacterial protein complexes that are crucial for infections and advancing the understanding of bacterial virulence pathways.
Helmholtz Centre for Infection Research • Hamburg
Leading research on structural biology of pathogens and their interaction with host cells.
Includes tracks like Intelligent Adaptive Systems (IAS).