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Michael S. Marks focuses his research on the mechanisms underlying intracellular protein transport, organelle biogenesis, and diseases that arise from dysfunction in these processes. Over his 25 years of research, he has specialized in understanding the biogenesis and function of melanosomes, the organelles responsible for melanin synthesis in pigmented cells. His laboratory utilizes various techniques, including biochemical analysis, live cell imaging, and genetic approaches, to explore how integral membrane proteins and sorting mechanisms contribute to organelle formation and function. Marks is also involved in studying the implications of genetic diseases like Hermansky-Pudlak syndrome, which affects melanosome formation and leads to significant visual impairment and susceptibility to skin cancers. Furthermore, his work addresses how these transport pathways impact blood clotting and immune responses, demonstrating a broad relevance of his findings to multiple biological systems and disease states.
Perelman School of Medicine, University of Pennsylvania • Philadelphia, PA
Teaching and conducting research in pathology and laboratory medicine.
Wharton Doctoral programs cover fields like Finance, Marketing, Management, and Operations, Information and Decisions.