Dr. Michael Miller

Biography

Michael B. Miller is an Assistant Professor of Pathology at Brigham and Women's Hospital and Harvard University. His research focuses on the fundamental mechanisms underlying neurodegenerative disorders, particularly Alzheimer's disease. Over the past century, significant progress has been made in understanding the specific proteins that misfold and accumulate in neurodegeneration. However, the development of disease-modifying therapies has been limited. Dr. Miller's work aims to bridge this gap by examining neurodegeneration from new perspectives and utilizing advanced research technologies. His studies involve investigating the genomic changes, specifically somatic mutations, that occur in brain cells during aging and disease. By analyzing the genomes of individual cells, his lab employs interdisciplinary approaches combining neurodegenerative disease biology, genomics, neuropathology, molecular biology, neuroscience, and computational biology. Notably, he innovates new methods in single-cell biology, including single-cell cytopathology and genome amplification. His ultimate goal is to develop new diagnostic and therapeutic strategies for neurodegeneration while mentoring enthusiastic students who are eager to understand the pathogenic mechanisms involved.

Research Interests