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Michael C. Milone, M.D., Ph.D., is an Associate Professor in the Department of Pathology and Laboratory Medicine at the University of Pennsylvania. His research focuses on T cell biology, specifically the applications of genetically-engineered T cells for the treatment of various diseases. Active research projects include developing chimeric antigen receptors (CARs) and engineering approaches to enhance their function and improve the safety of adoptive T cell therapy. Additionally, he investigates synthetic immunoreceptors for treating immune-mediated diseases and explores how co-stimulatory signals direct T cell metabolism and how that metabolism affects T cell function in tumors.
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