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Michel Leroux is a professor in the Department of Molecular Biology and Biochemistry at Simon Fraser University. His research focuses on identifying and characterizing proteins found in cilia, ancient microtubule-based organelles present in almost all human cells. Using the model organism C. elegans, he studies intraflagellar transport and the kinesin-dynein-dependent transport processes necessary for maintaining complex ciliary structures. His aim is to understand the makeup and function of the transition zone, which acts as a 'gate' that controls ciliary composition and function. Importantly, his biomedical research probes the molecular basis of human disorders resulting from ciliary dysfunction, such as Bardet-Biedl Syndrome and Meckel syndrome. These 'ciliopathies' are characterized by a wide range of ailments, including obesity, kidney and heart anomalies, blindness, skeletal malformations, and neurosensory impairment.
Department of Philosophy