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Professor Michele Vendruscolo has over 15 years of research experience focused on the development of methods for characterizing the structure, dynamics, and interactions of proteins in previously inaccessible states. His research primarily utilizes experimental data, particularly nuclear magnetic resonance spectroscopy, and employs structural restraints in molecular dynamics simulations. This innovative approach enables the acquisition of information about a variety of protein conformations, such as those populated during the folding process and protein interactions in complex environments. His work also addresses the generation of aggregate species associated with neurodegenerative disorders like Alzheimer's and Parkinson's diseases. By observing that proteins are expressed at levels close to their solubility limits, he has developed strategies aimed at enhancing quality control mechanisms to prevent or delay misfolding, leading to developments in therapeutic strategies for neurodegenerative diseases.
University of Cambridge • Cambridge, UK
Leading research in protein chemistry and biophysics with a focus on neurodegenerative diseases.
Standard postgraduate requirements for Department of Politics and International Studies (POLIS) and related humanities departments.